{"id":220,"date":"2021-11-15T19:22:48","date_gmt":"2021-11-15T19:22:48","guid":{"rendered":"https:\/\/bttalab.net\/plataforma-nodo\/boldo\/?page_id=220"},"modified":"2023-04-26T21:03:02","modified_gmt":"2023-04-26T21:03:02","slug":"metabolomica","status":"publish","type":"page","link":"https:\/\/bttalab.net\/ceap\/poroto\/metabolomica\/","title":{"rendered":"Linea 2: Metabol\u00f3mica"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#bfb7b4″ scene_position=”center” top_padding=”6%” constrain_group_1=”yes” bottom_padding=”6%” text_color=”custom” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” enable_shape_divider=”true” shape_divider_color=”#ffffff” shape_divider_position=”bottom” 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En la actualidad ya se han caracterizado diferentes variedades locales de poroto chileno, mediante cromatograf\u00eda l\u00edquida de alta eficiencia acoplada a espectroscopia UV (HPLC-DAD), espectrometr\u00eda de masas (HPLC-MS\/MSN) y RMN de alto campo.<\/p>\n

Adem\u00e1s, se ha identificado su huella qu\u00edmica, mediante perfiles de compuestos fen\u00f3licos y saponinas. La identificaci\u00f3n de las entidades qu\u00edmicas individuales y la cuantificaci\u00f3n de los compuestos principales ser\u00e1n par\u00e1metros relevantes para permitir la diferenciaci\u00f3n de la raza local chilena y para an\u00e1lisis multivariados.<\/p>\n

La bioactividad de los compuestos es una variable cr\u00edtica en las propiedades beneficiosas para la salud de esta planta alimenticia chilena. Al respecto, se est\u00e1 cuantificando los principales constituyentes y actividades como antioxidantes\/radicales libres, inhibici\u00f3n de enzimas relacionadas con el s\u00edndrome metab\u00f3lico, efecto antiinflamatorio medido por la inhibici\u00f3n de COX-1, COX-2 y LOX, citoprotecci\u00f3n contra oxidaci\u00f3n (H2<\/sub>O2<\/sub>) y estr\u00e9s por dicarbonilo, contenido celular de glutati\u00f3n reducido, inhibici\u00f3n de la peroxidaci\u00f3n lip\u00eddica en un modelo de digesti\u00f3n g\u00e1strica simulada, inhibici\u00f3n de la glicaci\u00f3n de prote\u00ednas.<\/p>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_content” full_screen_row_position=”middle” column_margin=”default” vertically_center_columns=”true” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”center” row_border_radius=”none” 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