{"id":223,"date":"2021-11-15T19:26:42","date_gmt":"2021-11-15T19:26:42","guid":{"rendered":"https:\/\/bttalab.net\/plataforma-nodo\/boldo\/?page_id=223"},"modified":"2022-08-08T15:54:33","modified_gmt":"2022-08-08T15:54:33","slug":"saludhumana","status":"publish","type":"page","link":"https:\/\/bttalab.net\/ceap\/poroto\/saludhumana\/","title":{"rendered":"Linea 3: Salud humana"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#bfb7b4″ scene_position=”center” top_padding=”6%” constrain_group_1=”yes” bottom_padding=”6%” text_color=”custom” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” enable_shape_divider=”true” shape_divider_color=”#ffffff” shape_divider_position=”bottom” 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Durante este periodo se ha estado evaluando el efecto de un compuesto bioactivo extra\u00eddo de semilla y hoja de poroto sobre una amplia variedad de actividades biol\u00f3gicas (efecto protector) sobre hemostasia (regulaci\u00f3n de la funci\u00f3n plaquetaria y coagulaci\u00f3n), endotelio (protecci\u00f3n de la funci\u00f3n endotelial), inmune (actividad inmunomoduladora), envejecimiento (protecci\u00f3n de la matriz extracelular d\u00e9rmica) efectos sobre la deposici\u00f3n de col\u00e1geno y la reticulaci\u00f3n de fibroblastos durante el envejecimiento en cultivo celular o en cultivo primario de piel d\u00e9rmica.<\/p>\n

Adem\u00e1s, se est\u00e1n analizando los principales mecanismos que asocian a los compuestos bioactivos que se asocian con la inhibici\u00f3n de v\u00edas de activaci\u00f3n plaquetaria y moduladores de v\u00edas mediadas por \u00f3xido n\u00edtrico en el endotelio.<\/p>\n

Finalmente, se est\u00e1n evaluando los mecanismos moleculares y celulares mediante la reacci\u00f3n en cadena de la polimerasa cuantitativa (qPCR) para genes de disfunci\u00f3n endotelial, entre otros, agregaci\u00f3n plaquetaria ex vivo, marcadores de activaci\u00f3n plaquetaria, bioenerg\u00e9tica mitocondrial plaquetaria, niveles plasm\u00e1ticos de prote\u00ednas secretoras plaquetarias, compartimento endotelial circulante y marcadores plasm\u00e1ticos.<\/p>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_content” full_screen_row_position=”middle” column_margin=”default” vertically_center_columns=”true” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”center” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” 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